Author

Fernando Palaguachi

Weill Cornell MedicineORCID 0000-0001-5403-7093Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adam L. OrriD· 3 shared Anna G. OrriD· 3 shared Samantha M. MeadowsiD· 3 shared Avital Licht-MuravaiD· 2 shared Constance Q. ZhouiD· 2 shared Daniel BarnettiD· 2 shared Till S. ZimmeriD· 2 shared Caroline BooraemiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Adam L. OrrORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeuroscienceNature MetabolismPeer-reviewedNov 4, 2025

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology

Daniel Barnett, Till S. Zimmer, Caroline Booraem…·Adam L. Orr

This study identifies mitochondrial complex III-derived ROS as a key driver of immunometabolic changes in astrocytes that contribute to dementia pathology.

36 citationstop 1%

mousebulk RNA-seq

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NeuroscienceCell ReportsPeer-reviewedMay 24, 2024

Astrocytes regulate spatial memory in a sex-specific manner

Samantha M. Meadows, Fernando Palaguachi, Minwoo Wendy Jang…·Anna G. Orr

The paper shows astrocytic GPCR signaling affects spatial memory differently in male and female mice, with opposing effects on memory based on receptor type and sex.

32 citationstop 3%

mouseexperimental assay

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NeuroscienceScience AdvancesPeer-reviewedApr 19, 2023

Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

Avital Licht-Murava, Samantha M. Meadows, Fernando Palaguachi…·Anna G. Orr

This study shows that TDP-43 accumulation in astrocytes impairs memory by altering antiviral pathways and chemokine signaling between astrocytes and neurons.

53 citationstop 1%

mousehuman

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