Adam L. Orr

This study shows that TDP-43 mutations in ALS/FTD reduce HSV-1 infection by disrupting cell-adhesion pathways and impairing viral entry.

This study identifies mitochondrial complex III-derived ROS as a key driver of immunometabolic changes in astrocytes that contribute to dementia pathology.

The paper shows astrocytic GPCR signaling affects spatial memory differently in male and female mice, with opposing effects on memory based on receptor type and sex.

The paper uses CRISPRi and FACS to compare effects of respiratory gene knockdown on ROS and ATP, identifying differential regulators of these processes.

This study shows that TDP-43 accumulation in astrocytes impairs memory by altering antiviral pathways and chemokine signaling between astrocytes and neurons.

The paper shows apoE4 increases VASP phosphorylation, disrupting actin interactions and affecting neurite outgrowth in Neuro-2a cells.