Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology
Daniel Barnett, Till S. Zimmer, Caroline Booraem, Fernando Palaguachi, Samantha M. Meadows, Haopeng Xiao, Man Ying Wong, Wenjie Luo, Li Gan, Edward T. Chouchani, Anna G. Orr, Adam L. Orr
This study identifies mitochondrial complex III-derived ROS as a key driver of immunometabolic changes in astrocytes that contribute to dementia pathology.
Nature Metabolism · Nov 4, 2025Peer-reviewedNeuroscience