Gianluca Amadei

This study identifies KLF7 as a key inducer of human pluripotency, showing its role in reprogramming somatic cells and enhancing chemical resetting to naive pluripotent stem cells.

This study develops a 3D model of human pluripotent epiblast formation and shows that TGF-beta dynamically maintains epithelial identity, independent of canonical pluripotency markers.

spinDrop improves single-cell sequencing by reducing noise and increasing detection rates, enabling high-quality molecular atlases of mouse brain development and organogenesis.

This study shows that ETiX mouse embryos, generated from stem cells, develop through gastrulation and neurulation, forming anterior brain regions and a beating heart, and recapitulate natural embryonic development.

This paper develops an in vitro mouse ESC model that recapitulates embryonic and extraembryonic development from day 5.5 to 8.5, showing similar transcriptional programs to natural embryos.