Magdalena Zernicka‐Goetz

The paper uses lineage tracing to show that fate restriction in mouse embryos and stem cell-derived models is asynchronous and not solely determined by cell identity.

The paper shows that asynchronous polarization in mouse embryos leads to heterogeneity in cell fate specification, linking early 4-cell stage asymmetries to later 8-cell stage lineage decisions.

The paper shows proteomic asymmetry in mouse and human embryos that influences lineage segregation.

The paper investigates how HIF1A-mediated pathways enhance euploid cell survival in chromosomally mosaic embryos by modulating hypoxia signaling and reducing aneuploidy.

This study identifies spindle-localized F-actin as critical for organizing polar MTOCs and ensuring accurate meiotic spindle formation and chromosome segregation in mammalian oocytes.

spinDrop improves single-cell sequencing by reducing noise and increasing detection rates, enabling high-quality molecular atlases of mouse brain development and organogenesis.

This paper introduces a stem cell-derived human embryo model that mimics post-implantation development and identifies SOX17's inhibitory role in anterior hypoblast-like cell specification.

This study identifies an E-cadherin-mediated division-independent mechanism for localizing the apical membrane initiation site in mouse embryonic stem cells.

This study shows that ETiX mouse embryos, generated from stem cells, develop through gastrulation and neurulation, forming anterior brain regions and a beating heart, and recapitulate natural embryonic development.

This paper develops an in vitro mouse ESC model that recapitulates embryonic and extraembryonic development from day 5.5 to 8.5, showing similar transcriptional programs to natural embryos.

This study uses human pluripotent stem cells to create an in vitro model of early human embryogenesis, recapitulating key developmental events from embryonic day 3 to day 9/10.

Endometrial assembloids of gland organoids and stromal cells reproduce midluteal cell states by scRNA-seq. Senescent decidual cells, tuned with dasatinib, track with whether co-cultured human blastocysts expand or stall.

This study identifies transcriptional control and protein clustering as mechanisms driving cell polarity establishment in early mouse embryos.

This study identifies the mechanism of first lineage segregation in human embryos through cell polarisation, showing it occurs at the 8-cell stage via F-actin and Par complex polarisation, with PLC activation and GATA3 regulation.