Author

Melanie Krause

European Molecular Biology LaboratoryORCID 0000-0003-3171-6098Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Dan LouiD· 2 shared Daniel Kirrmaier· 2 shared Krisztina GubiczaiD· 2 shared Lars Michael SteinmetziD· 2 shared Michael KnopiD· 2 shared Shengdi LiiD· 2 shared Artur YakimovichiD· 1 shared Daniel SchraivogeliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Dan LouORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 7, 2026

Cell organization and disturbance-mapping using image activated cell-profiling (CODIAC)

Melanie Krause, Dan Lou, Shengdi Li…·Lars Michael Steinmetz

CODIAC profiles spatial protein localization and abundance changes using image-enabled sorting and machine learning, detecting perturbation effects on the spatial proteome.

DOI 10.64898/2026.08.06.742695

imagingdeep learning

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Cell BiologybioRxivPreprintApr 1, 2026

Granularity screening identifies candidate genes involved in vaccinia virus induced LC3 lipidation

Melanie Krause, Artur Yakimovich, Noemi Vágó…·Jason Mercer

The paper uses an image-based screening approach to identify VACV genes that affect LC3 lipidation, revealing candidate viral membrane proteins involved in this process.

DOI 10.64898/2026.03.26.714436

imagingexperimental assay

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Molecular BiologybioRxivPreprintDec 16, 2025

Improved cloning-free one-step CRISPR-Cas12a-assisted tagging of mammalian genes using PCR generated reagents (PCR tagging)

Dan Lou, Daniel Kirrmaier, Melanie Krause…·Michael Knop

The paper improves CRISPR-Cas12a-assisted gene tagging in mammalian cells by enhancing HDR efficiency and reducing off-target integrations through modified cassettes and repair pathway modulation.

1 citation

humanCRISPR screen

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