Laura F. Landweber

A PIWI protein-dependent DNA N6-adenine methylation pathway in Oxytricha protects genomic sequences from deletion

The paper shows that PIWI protein-dependent DNA N6-adenine methylation protects genomic sequences from deletion in Oxytricha during nuclear differentiation.

Relaxed DNA substrate specificity of transposases involved in programmed genome rearrangement

This study investigates the DNA recognition properties of transposases in Oxytricha trifallax using heterologous assays and ChIP-seq, revealing relaxed sequence specificity and precise nuclear localization during genome rearrangement.

Widespread 3D genome reorganization precedes programmed DNA rearrangement in Oxytricha trifallax

The paper maps 3D genome organization in Oxytricha trifallax to understand its role in programmed DNA rearrangement during development.

SDRAP for annotating scrambled or rearranged genomes

SDRAP improves DNA rearrangement annotation by providing complete mappings, transparency, and flexibility for analyzing genomic data from different sources.

Transcribed germline-limited coding sequences in Oxytricha trifallax

The paper identifies and characterizes transcribed germline-limited ORFs in Oxytricha trifallax, showing they are developmentally regulated and eliminated during genome rearrangement.

Reconstitution of eukaryotic chromosomes and manipulation of DNA N6-methyladenine alters chromatin and gene expression

This study identifies a novel DNA 6mA methyltransferase in ciliates and shows 6mA affects chromatin organization and gene expression.

Russian Doll Genes and Complex Chromosome Rearrangements in Oxytricha trifallax

The paper describes the germline organization of highly scrambled genes in Oxytricha trifallax and introduces mathematical methods to analyze nesting and scrambling in chromosome rearrangements.