Jacqueline Hankinson

ZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers

This study identifies ZNFX1 as a multifunctional enzyme in innate immunity that couples RNA sensing to ubiquitin signaling and assembles into higher-order structures for signal amplification.

Viral protease-mediated polyprotein processing in human astroviruses

This study identifies cleavage sites and processing dynamics of astrovirus polyproteins, revealing conserved and divergent features between classical and non-classical strains.

The dynamics and strategy of RNA replication in astroviruses

This study investigates RNA replication dynamics in astroviruses using high-throughput sequencing, revealing a conserved premature termination model for subgenomic RNA production.

Flexibility and modulation of translation initiation in enterovirus genomes

This study shows enteroviruses can use two upstream AUGs for translation initiation, with the second AUG providing a competitive advantage in specific host environments.

Structural and mechanistic insights into translation initiation on the enterovirus Type 1 IRES

The paper investigates the structural and mechanistic details of translation initiation on the enterovirus Type 1 IRES using cryo-electron microscopy, revealing key RNA-RNA interactions critical for viral replication.