Dirk Werling

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

The paper identifies genetic variants in the bovine MRC1 gene, analyzes their impact on receptor expression, and explores their potential role in bovine tuberculosis resistance.

This study shows that H5N1 viruses' ability to adapt to bovine cells varies across genotypes and time, with key mutations in PB2 playing a role.

This study evaluates a glycoengineered vaccine against Haemonchus contortus in sheep, showing reduced worm burden and fecal egg shedding compared to non-glycoengineered and unvaccinated controls.

The paper uses targeted NGS to identify functional SNPs and pathways associated with IBD in GSDs, revealing genetic markers for treatment response.

This paper develops a method to produce bioactive vaccine antigens against Haemonchus contortus by glycoengineering insect cells to replicate nematode-specific glycan structures.

This study uses precision-cut bovine udder slices to investigate trained immunity indicators in mastitis, showing distinct cytokine and lipid mediator responses to zymosan and LPS stimulation.

The paper identifies methylation markers associated with age and BRD susceptibility in dairy cattle using RRBS, finding age-related and disease-specific differentially methylated genes.

This study uses multi-omics analysis to identify shifts in the chicken gastrointestinal ecosystem following vaccination and Eimeria tenella challenge, revealing distinct metabolic and microbial profiles associated with health, infection, and recovery.

This study compares the respiratory bioenergetics of human and bovine macrophages in response to M. bovis PPD and other TLR ligands, finding species-specific metabolic changes only in human macrophages.