Natural product-derived azaphilones are selective scaffolds for covalent lysine liganding in live cells
Wei Ding, Sophie Brameyer, Susanne H. Kirsch, Birthe Sandargo, Frank Surup, Stephan M. Hacker, Kirsten Jung, Stephan A. Sieber
This study identifies natural product-derived azaphilones as selective scaffolds for covalent lysine liganding in live cells, revealing bacterial chemotaxis as a major target pathway.
bioRxiv · Sep 28, 2026 · PreprintBiochemistry