Harshini Chandrashekar

FISHnet detects chromatin domains in single-cell sequential Oligopaints imaging data using graph theory and network modularity optimization.

The paper identifies cell-specific DNA loops linked to RNA polymerase II elongation during human neural differentiation and shows their role in gene expression changes.

The paper identifies multi-loop chromatin miswiring in FAD-mutant neurons that correlates with gene expression changes and DLX transcription factor activity.