Kenneth Pham

Learning induces persistent chromatin loops underlying robust gene expression during memory recall

The paper identifies persistent chromatin loops in hippocampal neurons after fear conditioning that correlate with gene expression changes during memory recall.

Persistent chromatin loops shape gene expression plasticity upon stimulation and restimulation of human neurons

The paper shows that persistent chromatin loops in human neurons influence gene expression plasticity during and after stimulation, with some loops maintaining repression or activation for up to five days.

FISHnet: Detecting chromatin domains in single-cell sequential Oligopaints imaging data

FISHnet detects chromatin domains in single-cell sequential Oligopaints imaging data using graph theory and network modularity optimization.

Mosaic H3K9me3 at BREACHes predicts synaptic gene expression associated with fragile X syndrome cognitive severity

The paper identifies H3K9me3 variation at BREACHes in FXS patients and shows it improves prediction of cognitive metrics when combined with FMRP and BREACH gene mRNA levels.