Jakub Rohlena

This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.

This study identifies that macrophage-secreted pyrimidine metabolites confer chemotherapy resistance in AML by inhibiting drug activation, and shows that targeting macrophage metabolism can restore drug sensitivity.

The paper shows that HSCs and Tregs work together to maintain extramedullary hematopoiesis during chronic inflammation.