Author
National University of SingaporeORCID 0009-0005-3849-4389Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Chuqi Wang, Yuhan Wang, Camillo Benetti…·Shruti Bhatt
This study identifies that macrophage-secreted pyrimidine metabolites confer chemotherapy resistance in AML by inhibiting drug activation, and shows that targeting macrophage metabolism can restore drug sensitivity.
Ahmed M. Mamdouh, Elyse A. Olesinski, Fang Qi Lim…·Shruti Bhatt
This study identifies that TP53 mutations in AML lead to resistance to VenAza therapy by blocking caspase-3/7 activation after mitochondrial outer membrane permeabilization.
Ahmed M. Mamdouh, Fang Qi Lim, Yang Mi…·Shruti Bhatt
This study identifies BIRC5 as a targetable vulnerability in TP53 mutant AML, showing that survivin/IAP inhibitors can overcome therapy resistance.