The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.

bioRxiv · Sep 15, 2026 · PreprintDevelopmental Biology

Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer

Deborah Y. Moss, Connor N. Brown, Andrew M. Shaw, Chris McCann, Nikita Lewis, Matilda Downs, Rebecca Wurelly, Ciara Cunningham, Aaron Philips, Niamh Doherty, Sarah Gallagher, William J. McDaid, Andrew J. Roe, Aisling Y. Coughlan, Brenton Cavanagh, , Emma M. Kerr

This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.

Nature Metabolism · Jul 23, 2026Peer-reviewedCancer Biology

TRANSSULFURATION LINKS ASPARTATE-ASPARAGINE METABOLISM AND REDOX HOMEOSTASIS TO DRIVE TUMOR GROWTH

Mirko Milošević, Kristina Dmytruk, Ahmad Y. Alghadi, Pavel Jakoubě, Julian Wong Soon, Petra Hyroššová, Muhammad Bin Munim, Sara Isabel Fernandes, Anna Shevzov-Zebrun, Robert Stanko, Isidora Mitric, Zuzana Čočková, Lukáš Kučera, Juan Fernández-García, Aleš Benda, , Jakub Rohlena

This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.

bioRxiv · Jul 13, 2026 · PreprintCancer Biology

Golgi-localised Guanylate-binding protein 5 enhances glycolysis in macrophages

Samuel J Lara Reyna, Barbara Clough, Will M. Channell, Callum McCarthy, Jonathan P. Barlow, Vesna S. Stanulović, Maarten Hoogenkamp, Jennie Roberts, Bryan P. Marzullo, Avinash R. Shenoy, Daniel A. Tennant, Eva‐Maria Frickel

This study identifies GBP5's role in enhancing glycolysis and maintaining Golgi integrity in IFNγ-stimulated macrophages.

bioRxiv · Feb 18, 2026 · PreprintImmunology