Andrew D A C Smith

The paper investigates how childhood adversity during sensitive periods affects DNA methylation in genes regulating developmental plasticity using a gene set-based approach.

This study shows that changes in socioeconomic environment during childhood affect DNA methylation at age 7, with middle childhood being a sensitive period for socioeconomic adversity's impact.

The paper assesses how changes in data versions and analytic methods affect the reproducibility of epigenome-wide association study results using the ALSPAC cohort.

This study maps DNA methylation changes across the human life course using data from 7,037 individuals, showing increased variability and age-related mean changes at specific CpG sites.

This study examines how time-varying childhood adversity affects DNA methylation across development, finding persistent effects at age 15 and resolving differences by adolescence.

This study identifies 40 CpG sites with differential methylation at age 7 linked to adversity exposure timing, showing infancy as a sensitive period for DNAm changes.

The paper examines how childhood adversity exposure affects epigenetic aging using DNA methylation clocks in children, finding that timing and type of adversity exposure significantly influence biological age.