Andrew J. Simpkin

Identification of Dynamic Genetic Influences on DNA Methylation from Birth to Adulthood

The paper identifies age-dependent methylation quantitative trait loci (longitudinal mQTLs) across the lifespan using blood DNAm data from two cohorts, finding consistent genotype-by-age effects and associations with multiple phenotypes.

An epigenome-wide analysis of DNA methylation, racialized and economic inequities, and air pollution

This study investigates how DNA methylation (DNAm) links racial discrimination, economic adversity, and air pollution to health inequities using epigenome-wide association analyses.

The impact of low input DNA on the reliability of DNA methylation as measured by the Illumina Infinium MethylationEPIC BeadChip

This study evaluates the reliability of DNA methylation measurements using the Illumina Infinium MethylationEPIC BeadChip at low DNA input levels, finding that 40ng DNA can be used with quality checks.

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach

The paper investigates how childhood adversity during sensitive periods affects DNA methylation in genes regulating developmental plasticity using a gene set-based approach.

Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies

The paper assesses how changes in data versions and analytic methods affect the reproducibility of epigenome-wide association study results using the ALSPAC cohort.

A prospective study of time-dependent exposures to childhood adversity and DNA methylation in childhood and adolescence

This study examines how time-varying childhood adversity affects DNA methylation across development, finding persistent effects at age 15 and resolving differences by adolescence.

Epigenome-wide change and variation in DNA methylation from birth to late adolescence

The paper analyzes DNA methylation changes across birth to late adolescence in two cohorts, finding widespread nonlinear changes and sex-specific patterns.

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

This study investigates the association between breastfeeding and DNA methylation changes in children and adolescents using data from the ALSPAC cohort, finding some consistent methylation sites linked to breastfeeding at ages 7 and 15-17.

Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study

This study examines how gestational age acceleration (GAA) relates to weight and height trajectories from birth to 10 years, finding initial increases in birth weight and height that reverse later in childhood.

Neurophysiological predictors of memory impairment in schizophrenia: decoupled slow-wave dynamics during non-REM sleep

The paper identifies impaired slow-wave and spindle coordination during NREM sleep in schizophrenia patients as predictors of memory consolidation deficits.

Sensitive periods for the effect of childhood adversity on DNA methylation: Results from a prospective, longitudinal study

This study identifies 40 CpG sites with differential methylation at age 7 linked to adversity exposure timing, showing infancy as a sensitive period for DNAm changes.

dmrff: identifying differentially methylated regions efficiently with power and control

Combining nearby CpG summary statistics by inverse-variance weighted meta-analysis holds false positives at the nominal level where comb-p and DMRcate inflate, and supports multi-cohort meta-analysis.

Predicting cellular aging following exposure to adversity: Does accumulation, recency, or developmental timing of exposure matter?

The paper examines how childhood adversity exposure affects epigenetic aging using DNA methylation clocks in children, finding that timing and type of adversity exposure significantly influence biological age.

An epigenome-wide association study of educational attainment (n = 10,767)

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.