Su Wang

This study shows that mutant IDH impairs PDGFB's chromatin binding, leading to chromosome instability and accelerated gliomagenesis.

This study uses scRNA-seq data to identify developmental-like cell states in brain tumors, suggesting potential cells of origin for medulloblastoma, glioma, and diffuse midline glioma.

The paper identifies hybrid cells in human glioma with both neuronal and glial electrophysiological and transcriptomic features using Patch-sequencing and a new computational tool.

This study develops CLIPPR, an algorithm that integrates single-cell and bulk RNA-seq data to improve meningioma classification and resolve benign-malignant confusion.

The paper identifies a dual mechanism for mating-type recognition in Tetrahymena thermophila using a novel protein complex formed by MTA and MTB.

This paper evaluates local hidden Markov models for genotype imputation, showing they can accurately impute common, uncommon, and rare variants.

This paper develops a privacy-aware kinship inference method for admixed populations using reference panels and homomorphic encryption to protect genetic data.

The paper introduces a secure imputation server that provides encrypted genotype imputation with provable privacy, demonstrating its utility through benchmarking and simulated GWAS.

SVAT securely outsources variant annotation and genotype aggregation using homomorphic encryption to protect genetic privacy during analysis and data sharing.

The paper presents a strategy for telomere-to-telomere assembly of ciliate macronuclear genomes using ultra-high coverage Nanopore data, successfully assembling complete genomes of two ciliate species.

The paper presents a pipeline for cryo-EM image processing of microtubules using RELION, enabling accurate determination of microtubule architecture and seam location with near-atomic resolution.