Benjamin Deneen

This study identifies local translation as a driver of glioblastoma tumor microtubes and invasion by linking subcellular protein synthesis to invasive cell states.

This study shows that combining CDK9 inhibitors with neuropsychiatric drugs reduces diffuse midline glioma growth by altering H3 dopaminylation and CaMKII signaling.

This study identifies specific developmental epigenomic states that enable ZFTA-RELA-driven ependymoma formation and reveals how these states shape tumor progression.

This study investigates EZHIP mutations in pediatric brain tumors, showing their presence in new tumor types and revealing their role in neuronal-like gene programs and polyamine metabolism repression.

This study shows that mutant IDH impairs PDGFB's chromatin binding, leading to chromosome instability and accelerated gliomagenesis.

This study uses scRNA-seq data to identify developmental-like cell states in brain tumors, suggesting potential cells of origin for medulloblastoma, glioma, and diffuse midline glioma.

The paper identifies hybrid cells in human glioma with both neuronal and glial electrophysiological and transcriptomic features using Patch-sequencing and a new computational tool.

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.

This study shows inhibitory neuron activity and astrocytic GABABR are necessary for astrocyte morphogenesis, with region-specific transcription factors regulating this process.

The paper shows neuronal activity induces Slc22a3 in astrocytes, which affects histone serotonylation and GABA release, leading to olfactory deficits.

This study identifies transcriptomic signatures of human astrocytes across age, sex, and disease states, revealing changes in synaptic function, ionic homeostasis, and tumor microenvironment interactions.

scRegulocity detects local RNA velocity patterns in single-cell RNA-seq embeddings to identify regulatory changes and cell state transitions.