Aaron M. Kershner

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

The paper identifies genes that function redundantly with lst-1 or sygl-1 to maintain C. elegans germline stem cells through genetic screens.

The paper identifies regions in the C. elegans LST-1 protein that mediate its function in stem cell self-renewal through interaction with the FBF RNA-binding protein.