Endre Sebestyén

The paper develops 4f-SAMMY-seq to map euchromatin and heterochromatin based on accessibility and solubility, and reconstructs their 3D compartmentalization in one experiment.

This study shows that CHD8 suppression reduces H3K36me3 levels and alters alternative splicing of ~2000 genes, linking CHD8 to RNA processing and ASD.

SplicingFactory analyzes RNA isoform diversity across conditions and identifies genes with diversity changes linked to SF3B1 mutations.

The paper identifies early chromatin structural changes in HGPS using a new method, showing Polycomb target gene deregulation linked to lamin-associated domain disruption.

The paper introduces ChIC, a ChIP-seq quality assessment framework that evaluates enrichment profile shape, providing a reliable score for data quality.