Koustav Pal

The paper shows that increased 4R Tau RNA contributes to motor neuron degeneration in ALS by reducing viability and that targeting this RNA could be therapeutic.

The paper identifies widespread isoform switches of transcription factors across human tissues and predicts their functional consequences.

The paper develops 4f-SAMMY-seq to map euchromatin and heterochromatin based on accessibility and solubility, and reconstructs their 3D compartmentalization in one experiment.

This paper introduces a statistical framework integrating 3D chromatin architecture to improve enhancer-target gene pairing and benchmark it against existing methods.

The paper introduces ChIC, a ChIP-seq quality assessment framework that evaluates enrichment profile shape, providing a reliable score for data quality.