Chiara Lanzuolo

This study shows that LIN28A mediates RNA-dependent interactions with PRC2 to regulate chromatin dynamics and neuronal differentiation in ESCs.

This study shows that LBR nucleoplasmic domains regulate X-chromosome solubility and nuclear organization during neural differentiation in mouse cells.

This study identifies the molecular interactions between lamin isoforms and chromatin, revealing their role in chromatin organization and epigenetic regulation.

This study shows Sorafenib causes muscle wasting by disrupting chromatin regulators, leading to transcriptional changes and impaired muscle function.

The paper develops 4f-SAMMY-seq to map euchromatin and heterochromatin based on accessibility and solubility, and reconstructs their 3D compartmentalization in one experiment.

The paper identifies early chromatin structural changes in HGPS using a new method, showing Polycomb target gene deregulation linked to lamin-associated domain disruption.

The paper introduces ChIC, a ChIP-seq quality assessment framework that evaluates enrichment profile shape, providing a reliable score for data quality.