Author

Karthikeyan Mythreye

University of Alabama at BirminghamORCID 0000-0001-5478-0098Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Amal Taher ElhawiD· 3 shared Katherine M. AirdiD· 3 shared Nadine HempeliD· 3 shared Priscilla W. TangiD· 3 shared Shriya KamlapurkariD· 3 shared Sierra R. WhiteiD· 3 shared Ya-Yun ChengiD· 3 shared Zaineb JavediD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Amal Taher ElhawORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 2, 2026

Aging increases ovarian cancer growth, metastasis, and immunosuppression that can be alleviated by inhibiting hedgehog signaling

Asha Kumari, Mohamed Halaby Elbahoty, Resha Rajkarnikar…·Karthikeyan Mythreye

This study shows aging promotes ovarian cancer growth and immunosuppression, which can be mitigated by inhibiting Hedgehog signaling in mice and correlates with immune checkpoint resistance in humans.

DOI 10.64898/2025.12.23.695206

mousehuman

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Cancer BiologyCancer ResearchPeer-reviewedApr 16, 2026

RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis

Amal Taher Elhaw, Priscilla W. Tang, Ya-Yun Cheng…·Nadine Hempel

This study identifies RHOV as a detachment-sensitive Rho GTPase critical for ovarian cancer peritoneal metastasis by enhancing anoikis resistance and cytoskeletal remodeling.

DOI 10.1158/0008-5472.can-25-4056

humanbulk RNA-seq

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Cancer BiologyCancer Research CommunicationsPeer-reviewedJul 1, 2025

Loss of the predicted cell adhesion molecule MPZL3 promotes EMT and chemoresistance in ovarian cancer

Ya-Yun Cheng, Beth L. Worley, Zaineb Javed…·Nadine Hempel

This study shows that loss of MPZL3 promotes EMT and chemoresistance in ovarian cancer by reducing adhesion and increasing drug resistance.

2 citations

humanexperimental assay

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Cancer BiologyGynecologic OncologyPeer-reviewedJan 29, 2024

GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15

Caroline A. Chang, Ya-Yun Cheng, Shriya Kamlapurkar…·Nadine Hempel

This study shows GPX3 is necessary for ovarian cancer growth in vivo and promotes GDF15 expression, linking it to immune checkpoint inhibitor response.

17 citations

mousebulk RNA-seq

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