Author

Ya-Yun Cheng

University of PittsburghORCID 0000-0002-2472-0577Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Amal Taher ElhawiD· 2 shared Karthikeyan MythreyeiD· 2 shared Katherine M. AirdiD· 2 shared Nadine HempeliD· 2 shared Priscilla W. TangiD· 2 shared Sarah Al-SaadiD· 2 shared Shriya KamlapurkariD· 2 shared Sierra R. WhiteiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Amal Taher ElhawORCID

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3 papers

Recent·Most cited

RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis

Amal Taher Elhaw, Priscilla W. Tang, Ya-Yun Cheng, Shriya Kamlapurkar, Zaineb Javed, Sarah Al-Saad, Sierra R. White, Ahmed Emam Abdelnaby, Hannah Khan, Alex Seok Choi, Alexa L. Mattheyses, Aidan R. Cole, Yeon Soo Kim, Huda Issa Atiya, Mohamed Trebak, , Nadine Hempel

This study identifies RHOV as a detachment-sensitive Rho GTPase critical for ovarian cancer peritoneal metastasis by enhancing anoikis resistance and cytoskeletal remodeling.

Cancer Research · Apr 16, 2026Peer-reviewedCancer Biology

Loss of the predicted cell adhesion molecule MPZL3 promotes EMT and chemoresistance in ovarian cancer

Ya-Yun Cheng, Beth L. Worley, Zaineb Javed, Amal Taher Elhaw, Priscilla W. Tang, Sarah Al-Saad, Shriya Kamlapurkar, Sierra R. White, Apoorva Uboveja, Karthikeyan Mythreye, Katherine M. Aird, Traci A. Czyzyk, Nadine Hempel

This study shows that loss of MPZL3 promotes EMT and chemoresistance in ovarian cancer by reducing adhesion and increasing drug resistance.

Cancer Research Communications · Jul 1, 2025Peer-reviewedCancer Biology

Rapid, modular, and cost-effective generation of donor DNA constructs for CRISPR-based gene knock-in

Yi-Jiun Chen, Ya-Yun Cheng, Weikang Wang, Xiao‐Jun Tian, Daniel E. Lefever, David A. Taft, Jingyu Zhang, Jianhua Xing

This paper develops a modular Gibson assembly method for efficient and cost-effective CRISPR donor DNA construct generation, showing improved assembly efficiency compared to conventional methods.

Biology Methods and Protocols · Jan 1, 2020Peer-reviewedMolecular Biology