Author

Shriya Kamlapurkar

Fred Hutch Cancer CenterORCID 0000-0002-2686-3387Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Alice H. BergeriD· 2 shared Amal Taher ElhawiD· 2 shared Karthikeyan MythreyeiD· 2 shared Katherine M. AirdiD· 2 shared Nadine HempeliD· 2 shared Priscilla W. TangiD· 2 shared Sarah Al-SaadiD· 2 shared Sierra R. WhiteiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Alice H. BergerORCID

Author profile →

4 papers

Recent·Most cited

RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis

Amal Taher Elhaw, Priscilla W. Tang, Ya-Yun Cheng, Shriya Kamlapurkar, Zaineb Javed, Sarah Al-Saad, Sierra R. White, Ahmed Emam Abdelnaby, Hannah Khan, Alex Seok Choi, Alexa L. Mattheyses, Aidan R. Cole, Yeon Soo Kim, Huda Issa Atiya, Mohamed Trebak, , Nadine Hempel

This study identifies RHOV as a detachment-sensitive Rho GTPase critical for ovarian cancer peritoneal metastasis by enhancing anoikis resistance and cytoskeletal remodeling.

Cancer Research · Apr 16, 2026Peer-reviewedCancer Biology

Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

Mary C. Rominger, Siobhan O’Brien, Saksham Gupta, Sitapriya Moorthi, Maria V. McSharry, Shriya Kamlapurkar, Amy R. Lowe, Annie Waldum, April Lo, Fujiko F. Duke, Feinan Wu, Mark B. Headley, Elizabeth A. Cromwell, Raisa A. Glabman, Amanda L. Koehne, Alice H. Berger

This paper develops a mouse model of RIT1M90I-driven lung cancer and identifies YAP/TEAD as a therapeutic target for RIT1-mutant lung cancer.

Cell Reports · Sep 25, 2025Peer-reviewedCancer Biology

Loss of the predicted cell adhesion molecule MPZL3 promotes EMT and chemoresistance in ovarian cancer

Ya-Yun Cheng, Beth L. Worley, Zaineb Javed, Amal Taher Elhaw, Priscilla W. Tang, Sarah Al-Saad, Shriya Kamlapurkar, Sierra R. White, Apoorva Uboveja, Karthikeyan Mythreye, Katherine M. Aird, Traci A. Czyzyk, Nadine Hempel

This study shows that loss of MPZL3 promotes EMT and chemoresistance in ovarian cancer by reducing adhesion and increasing drug resistance.

Cancer Research Communications · Jul 1, 2025Peer-reviewedCancer Biology

Discovery of synthetic lethal and tumor suppressive paralog pairs in the human genome

Phoebe C. R. Parrish, James D. Thomas, Austin M. Gabel, Shriya Kamlapurkar, Robert K. Bradley, Alice H. Berger

The paper identifies synthetic lethal and tumor suppressive paralog pairs in the human genome using a CRISPR-based approach, revealing new drug targets and essential gene families.

Cell Reports · Aug 1, 2021Peer-reviewedGenomics