Thomas Nyström

The paper uses high-content imaging and machine learning to study how perturbing essential genes affects subcellular organization in yeast, revealing cascade effects and a threshold for cell death.

The paper compares the behavior of Hsp104 fluorescent fusions in yeast, finding that fluorescent tags and fluorophores can alter molecular behavior in protein quality control and aging research.

The paper investigates the functional differences between Ssa4 and Ssa1/2 Hsp70s in yeast, showing Ssa4 can compensate for Ssa1/2 loss in some aspects of protein quality control but not all, and that Hsp104-dependent aggregate clearance is not essential for longevity.