Carles Pons

Organelle interdependencies underlie the collapse of eukaryotic intracellular organization during cell death and aging

The paper uses high-content imaging and machine learning to study how perturbing essential genes affects subcellular organization in yeast, revealing cascade effects and a threshold for cell death.

The modifiers that cause changes in gene essentiality

The paper identifies suppressor variants that alter gene essentiality across yeast strains, revealing context-dependent genetic mechanisms.

Conservation of the genetic interaction network between two yeast species

This study quantifies genetic interaction conservation between two yeast species, finding significant conservation among functionally related genes but reduced conservation due to gene duplication.

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

Co-occurrence of essential gene dispensability and bypass suppressor mutations across species

The paper examines dispensable essential genes and their association with bypass suppressor mutations across species, revealing distinct phylogenetic properties and evolutionary implications.

Global analysis of suppressor mutations that rescue human genetic defects

The paper identifies suppressor mutations that rescue human genetic defects by analyzing 2,400 papers and predicting suppressor genes in the human genome.

PIQUE: An ImageJ plugin for the quantification of toroidal nuclei in biological images

PIQUE is an ImageJ plugin that automates the quantification of toroidal nuclei in biological images, matching manual counts and identifying micronuclei for CIN analysis.

A map of binary SARS-CoV-2 protein interactions implicates host immune regulation and ubiquitination

The paper maps binary SARS-CoV-2 protein interactions with host proteins, identifying key processes like immune signaling and ubiquitination, and suggests therapeutic targets.

Diverse natural variants suppress mutations in hundreds of essential genes

The paper measures how natural genetic variation can suppress mutations in essential yeast genes, finding that 35% of tested genes can be suppressed by modifier genes in different backgrounds.

Binary Interactome Models of Inner- Versus Outer-Complexome Organization

The paper constructs a high-quality yeast binary interactome map and compares inner- and outer-complexome organization, finding the outer-complexome contains more interactions and exhibits higher functional heterogeneity.

Analysing the Yeast Complexome - The Complex Portal rising to the challenge

The paper curates and expands the yeast complexome, showing increased genetic interactions and functional links among complex members.

A reference map of the human protein interactome

The paper presents HuRI, a comprehensive human protein-protein interaction map, and demonstrates its utility in understanding cellular function and disease mechanisms.

Expanding the Atlas of Functional Missense Variation for Human Genes

This paper develops a deep mutational scanning framework to map functional missense variants in human genes and applies it to four proteins, identifying pathogenic variants and showing scalability to disease genes.