Jennifer N. Bourne

This study shows that deleting mTORC2 in oligodendrocyte progenitor cells causes hypomyelination specifically in the corpus callosum, but not the spinal cord.

The paper uses single-cell sequencing to show brain and spinal cord oligodendroglia are transcriptionally distinct, with mTOR playing a key role in cholesterol biosynthesis and myelin maintenance.

The paper demonstrates that extrasynaptic glutamatergic signaling in olfactory bulb glomeruli creates a thresholding effect by balancing excitation and inhibition, allowing only strong stimuli to produce an output.