Author

Marisa A. Jeffries

Children's Hospital of PhiladelphiaORCID 0000-0002-2486-0457Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Adeline L. VanderveriD· 1 shared Akshata Almad· 1 shared Anjali Bhagavatula· 1 shared Annemarie D’Alessandro· 1 shared Asako TakanohashiiD· 1 shared Azadeh K. TafreshiiD· 1 shared Eric D. MarshiD· 1 shared Isis Moraes OrnelasiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Adeline L. VanderverORCID

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2 papers

Recent·Most cited

NeuroscienceMolecular TherapyPeer-reviewedJan 20, 2026

Therapeutic suppression of Tubb4a rescues H-ABC leukodystrophy

Sunetra Sase, Julia Liao Hacker, Prabhat R. Napit…·Adeline L. Vanderver

This study shows that suppressing Tubb4a with an ASO improves symptoms and extends lifespan in a mouse model of H-ABC leukodystrophy.

1 citation

mouseexperimental assay

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NeurosciencebioRxivPreprintOct 22, 2020

Single-cell Sequencing Reveals Brain/Spinal Cord Oligodendrocyte Precursor Heterogeneity and Requirement for mTOR in Cholesterol Biosynthesis and Myelin Maintenance

Luipa Khandker, Marisa A. Jeffries, Yun‐Juan Chang…·Teresa L. Wood

The paper uses single-cell sequencing to show brain and spinal cord oligodendroglia are transcriptionally distinct, with mTOR playing a key role in cholesterol biosynthesis and myelin maintenance.

3 citations

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