Teresa L. Wood

Insulin-Like Growth Factor 1 Receptor Regulates Breast Cancer Cell Adhesion through Beta-1 Integrin

This study shows that IGF1R regulates breast cancer cell adhesion through β1 integrin, with both IGF-1 stimulation and IGF1R knockdown increasing adhesion by removing IGF1R from the cell surface.

Extracellular Matrix Physical Properties Regulate Cancer Cell Morphological Transitions in 3D Hydrogel Microtissues

This study shows that ECM physical properties, not chemistry, determine cancer cell morphology in 3D hydrogels, with cells adopting elongated or clustered states based on matrix stiffness.

Identifying Antisense Oligonucleotides for Targeted Inhibition of Insulin Receptor Isoform A

This study develops an antisense oligonucleotide that selectively targets IR-A mRNA in cancer cells with minimal effect on IR-B.

mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system

This study shows that deleting mTORC2 in oligodendrocyte progenitor cells causes hypomyelination specifically in the corpus callosum, but not the spinal cord.

Single-cell Sequencing Reveals Brain/Spinal Cord Oligodendrocyte Precursor Heterogeneity and Requirement for mTOR in Cholesterol Biosynthesis and Myelin Maintenance

The paper uses single-cell sequencing to show brain and spinal cord oligodendroglia are transcriptionally distinct, with mTOR playing a key role in cholesterol biosynthesis and myelin maintenance.

Subventricular zone adult mouse neural stem cells and human glioblastoma stem cells require insulin receptor for self-renewal

This study shows that the insulin receptor is essential for maintaining adult neural stem cells and inhibiting glioblastoma stem cell self-renewal.