Cassandra L. Cole

This study investigates how RGS10 modulates NFκB subunit transcription and inflammatory cytokine profiles in peritoneal macrophages through experimental stimulation and transcript analysis.

The paper investigates RGS10 levels in Parkinson's Disease (PD) patients and mice, finding reduced RGS10 in CSF and peripheral immune cells, and showing RGS10 deficiency exacerbates immune dysregulation in chronic systemic inflammation.

This study shows that the Alzheimer's protective PLCG2-P522R variant affects peripheral macrophage function differently in males and females.

This study investigates GPNMB upregulation and MITF dysregulation in progranulin-deficient macrophages, linking them to early-stage neurodegenerative disease mechanisms.

This study shows that LC injury modifies neuroinflammation in the ventral midbrain during DSS-induced colitis, highlighting the neuroprotective role of the locus coeruleus.

This study examines the gut-brain axis in a mouse colitis model, identifying immune activation, oxidative stress, and myelination disruptions in the brain linked to intestinal permeability.