RGS10 Attenuates Systemic Immune Dysregulation Induced by Chronic Inflammatory Stress
Janna E. Jernigan, Hannah A. Staley, Zachary Baty, MacKenzie L. Bolen, Beatriz Nuñes Gomes, Jenny Holt, Cassandra L. Cole, Noelle K. Neighbarger, Kruthika Dheeravath, Andrea R. Merchak, Kelly B. Menees, Stephen A. Coombes, Malú G. Tansey
The paper investigates RGS10 levels in Parkinson's Disease (PD) patients and mice, finding reduced RGS10 in CSF and peripheral immune cells, and showing RGS10 deficiency exacerbates immune dysregulation in chronic systemic inflammation.
Journal of Neuroinflammation · Feb 24, 2025Peer-reviewedImmunology