NeuroscienceAngewandte Chemie International EditionPeer-reviewed
Site-specific hyperphosphorylation of tau inhibits its fibrillization in vitro, blocks its seeding capacity in cells, and disrupts its microtubule binding; Implications for the native state stabilization of tau
Mahmood Haj‐Yahya, Pushparathinam Gopinath, Kolla Rajasekhar…·Hilal Ahmed Lashuel
This study shows that site-specific hyperphosphorylation of tau inhibits its aggregation and microtubule binding, challenging the hyperphosphorylation hypothesis of tau pathology.
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