Hilda Mirbaha

The paper shows that seed-competent tau monomer (Ms) forms before insoluble fibrils in PS19 tauopathy mice, initiating pathology in a phosphorylation-independent manner.

This study shows that site-specific hyperphosphorylation of tau inhibits its aggregation and microtubule binding, challenging the hyperphosphorylation hypothesis of tau pathology.

The paper identifies inert and seed-competent tau monomers, showing structural differences that influence aggregation potential.