Nelson Rebola

Focal drug uncaging for the precise control of endogenous nicotinic receptors in behaving mice

This paper introduces a method to control endogenous nicotinic receptors in mice using light-activated drug release, revealing circuit-specific effects previously hidden by systemic administration.

Precise calcium-to-spike inference using biophysical generative models

The paper develops biophysically-inspired models to improve spike inference from calcium imaging by accounting for kinetic features of fluorescent indicators.

A dendritic substrate for temporal diversity of cortical inhibition

The paper identifies distinct dendritic integration strategies in two types of cortical interneurons that lead to different temporal dynamics of inhibition.

Feedforward and disinhibitory circuits differentially control activity of cortical somatostatin-positive interneurons during behavioral state transitions

The paper shows that locomotor activity recruits SST-INs in S1 but not V1 cortex, suggesting feedforward sensory pathways and neuromodulation influence their activity during behavioral state transitions.

Activity-dependent modulation of NMDA receptors by endogenous zinc shapes dendritic function in cortical neurons.

The paper shows that vesicular zinc modulates NMDA receptor activity in cortical neurons, affecting dendritic function and synaptic plasticity under in vivo-like conditions.

The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo

This study identifies the Hedgehog pathway as a regulator of GlyT2 expression and transport activity in vitro and in vivo.

An unconventional GABAergic circuit differently controls pyramidal neuron activity in two visual cortical areas via endocannabinoids

The paper identifies a differential role of CB1-expressing interneurons in controlling pyramidal neuron activity in primary and secondary visual cortical areas through distinct endocannabinoid mechanisms.

Distinct nanoscale calcium channel and synaptic vesicle topographies contribute to the diversity of synaptic function

The paper investigates the nanoscale arrangement of calcium channels and synaptic vesicles in cerebellar synapses, finding distinct topographies that correlate with synaptic strength and functional diversity.

Stability, affinity and chromatic variants of the glutamate sensor iGluSnFR

The paper introduces variants of the glutamate sensor iGluSnFR with improved brightness, broader concentration detection, and different emission colors for enhanced in vivo imaging.