Ben Vanderkruk

The paper identifies SWING regions as chromatin domains that mediate gene regulation through interactions with nuclear speckles and the lamina, showing their role in development and disease.

This study shows that disrupting the WRAD core in pancreatic cancer leads to DNA replication errors, immune response activation, and improved response to immune checkpoint inhibitors.

This study shows that H3K4 trimethylation is necessary for the functional maturation of pancreatic islet endocrine cells by activating genes involved in glucose-stimulated insulin secretion.