Jocelyn Bégin

This study shows that HTT CAA/CCA-loss variants increase toxicity in Huntington disease models independently of somatic repeat instability.

This study identifies splicing dysregulation in RNA processing and neuronal function genes in early and late-stage Huntington's disease using an isogenic neuronal cell model and post-mortem data.

This study shows that H3K4 trimethylation is necessary for the functional maturation of pancreatic islet endocrine cells by activating genes involved in glucose-stimulated insulin secretion.