Author

Iris Nira Smith

Cleveland ClinicORCID 0000-0001-5560-8871Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Approach:simulation· 1

Frequent Co-Authors

Charis EngiD· 2 shared Andreas BrunklausiD· 1 shared Dennis LaliD· 1 shared Eduardo Pérez‐PalmaiD· 1 shared Feixiong ChengiD· 1 shared Hyunbum JangiD· 1 shared Ingo HelbigiD· 1 shared Ludovica MontanucciiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Charis EngORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiophysicsbioRxivPreprintFeb 19, 2024

Molecular dynamics simulations reveal molecular mechanisms for the gain and loss of function effects of four SCN2A variants

Nisha Bhattarai, Ludovica Montanucci, Tobias Brünger…·Dennis Lal

The paper uses molecular dynamics simulations to analyze four SCN2A variants, revealing how they affect channel structure and function, with R937C being the most unstable.

DOI 10.1101/2024.02.19.580930

biophysical modelingprotein folding & dynamics

𝕏 PostBluesky

Molecular BiologyiSciencePeer-reviewedApr 19, 2021

The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane

Hyunbum Jang, Iris Nira Smith, Charis Eng, Ruth Nussinov

This study uses explicit solvent simulations to reveal how PTEN interacts with phosphoinositide-enriched membranes, elucidating its mechanism of activation and membrane anchoring.

64 citations

simulation

𝕏 PostBluesky