Author

Hauke Thiesler

Medizinische Hochschule HannoverORCID 0000-0001-5561-3988Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Aleksandra Alo· 1 shared Alexander E. DityateviD· 1 shared Alexei GorelikiD· 1 shared Alexey V. PshezhetskyiD· 1 shared Angelo PalmigianoiD· 1 shared Bénédicte AmilhoniD· 1 shared Bhushan NagariD· 1 shared Brian BiggeriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Aleksandra Alo

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2 papers

Recent·Most cited

BiochemistryJournal of Clinical InvestigationPeer-reviewedJun 17, 2025

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

TianMeng Xu, Rachel Heon‐Roberts, Travis Moore…·Alexey V. Pshezhetsky

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

5 citations

humanmouse

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 13, 2025

Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits

Loris Frroku, Shaobo Jia, Stepan E. Aleshin…·Alexander E. Dityatev

The paper shows that short polysialic acid (NANA12) improves cognitive and synaptic function in very old mice without altering neuronal structure or inflammation markers.

2 citations

mousestatistical model

𝕏 PostBluesky