Brian Bigger

Collagen fibril formation at the plasma membrane occurs independently from collagen secretion

The paper investigates collagen fibril formation in fibroblasts, showing it occurs at the plasma membrane independently of secretion and involves endocytosis.

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission

This study shows that lysosomal storage diseases cause synaptic structure and neurotransmission defects before cognitive symptoms appear in mice and humans.