Author

Alexei Gorelik

McGill UniversityORCID 0000-0001-6236-4633Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Alexey V. PshezhetskyiD· 1 shared Angelo PalmigianoiD· 1 shared Bénédicte AmilhoniD· 1 shared Bhushan NagariD· 1 shared Brian BiggeriD· 1 shared Christopher W. CairoiD· 1 shared Domenico GarozzoiD· 1 shared Hauke ThiesleriD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Alexey V. PshezhetskyORCID

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1 paper

Recent·Most cited

BiochemistryJournal of Clinical InvestigationPeer-reviewedJun 17, 2025

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

TianMeng Xu, Rachel Heon‐Roberts, Travis Moore…·Alexey V. Pshezhetsky

This study shows that reduced NEU1 activity in neurological MPS leads to hypersialylation of brain glycoproteins, contributing to CNS pathology through disrupted synaptogenesis and behavior.

5 citations

humanmouse

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