Annalisa Pastore

This study uses vacuum-dried ATR-FTIR spectroscopy to analyze the structural features and HDX kinetics of GCN4, revealing distinct Amide I bands in dry samples.

This study shows DNA supercoiling affects GCN4-DNA binding stability and conformational dynamics through experimental and simulation approaches.

The paper shows that amygdala TDP-43 pathology correlates with behavioural dysfunction and ferritin accumulation in sporadic ALS.

This study shows that CLR01, a supramolecular tweezer, reduces Atx3 aggregation by binding to a specific site, delaying fibril formation and improving symptoms in SCA3 models.

This study investigates clinically relevant cytochrome c variants using bioinformatics and molecular dynamics to reveal structural and functional changes linked to thrombocytopenia 4.

The paper investigates the unfolding pathways of the yeast protein Yfh1 under pressure and different temperatures using high-pressure NMR, revealing similarities and differences in the mechanisms of denaturation.

This study uses an RNA aptamer to detect TDP-43 aggregation and shows that nuclear TDP-43 pathology and STMN-2 cryptic splicing occur before clinical symptoms in ALS.

This study identifies genetic loci associated with impulsivity in juvenile myoclonic epilepsy and links them to synaptic assembly genes and SLCO5A1 function.

The paper analyzes two deep mutational scanning experiments to show that protein aggregation affects molecular evolution differently in distinct cellular contexts.

This paper demonstrates that TDP-43 paralogs in the killifish N. furzeri form amyloid-like aggregates during ageing, suggesting the fish as a model for TDP-43-related neurodegenerative diseases.

The paper applies direct coupling analysis to study proteins involved in iron-sulfur cluster biogenesis, revealing structural and interaction features of these proteins.