RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Holly Spence, Fergal M. Waldron, Rebecca S. Saleeb, Anna‐Leigh Brown, Olivia M. Rifai, Martina Gilodi, F.L. Read, Kristine Roberts, Gillian Milne, D. Wilkinson, Judi O’Shaughnessy, Annalisa Pastore, Pietro Fratta, Neil A. Shneider, Gian Gaetano Tartaglia, , Jenna M. Gregory
This study uses an RNA aptamer to detect TDP-43 aggregation and shows that nuclear TDP-43 pathology and STMN-2 cryptic splicing occur before clinical symptoms in ALS.
bioRxiv · Oct 24, 2023 · PreprintNeuroscience