Author

Alexandre Zacharie Kadhim

National Institute for Health and Care ResearchORCID 0000-0001-5600-0411Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Amy Fong-Yuk PooniD· 1 shared Anik MuhuriiD· 1 shared Deema AlhusariiD· 1 shared Dong-Yeop LeeiD· 1 shared Fernando LopeziD· 1 shared Forum BhanshaliiD· 1 shared Francis C. LynniD· 1 shared Guo ChengiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Amy Fong-Yuk PoonORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 12, 2026

Characterisation of Genetically-Derived Patient Clusters Highlights Genetic Heterogeneity of Inflammatory Bowel Disease

Fernando Lopez, Alexandre Zacharie Kadhim, Zachary Green…·James John Ashton

The paper uses GenePy scores and clustering to identify genetic clusters in IBD patients, finding NOD2 and NLRP1 as significant drivers with phenotypic associations.

DOI 10.64898/2026.10.05.754100

humanwhole-exome sequencing

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GeneticsPLoS GeneticsPeer-reviewedDec 9, 2019

Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans

Naomi Shomer, Alexandre Zacharie Kadhim, Jennifer M. Grants…·Stefan Taubert

This study shows that MDT-15 and HIZR-1 cooperate to regulate metal detoxification and zinc storage in C. elegans, with partial conservation in mammals.

27 citations

C. elegansexperimental assay

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