Dong-Yeop Lee

Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior

The paper shows that blocking programmed cell death in C. elegans leads to extra neurons that alter specific behaviors like reversal frequency and duration.

Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans

This study shows that MDT-15 and HIZR-1 cooperate to regulate metal detoxification and zinc storage in C. elegans, with partial conservation in mammals.

C. elegans Mediator 15 permits low temperature-induced longevity via regulation of lipid and protein homeostasis

This study shows that MDT-15 regulates lipid composition and protein homeostasis to enable longevity at low temperatures in C. elegans.