Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans
Naomi Shomer, Alexandre Zacharie Kadhim, Jennifer M. Grants, Xuanjin Cheng, Deema Alhusari, Forum Bhanshali, Amy Fong-Yuk Poon, Michelle Y. Y. Lee, Anik Muhuri, Jung In Park, James Shih, Dong-Yeop Lee, Seung‐Jae Lee, Francis C. Lynn, Stefan Taubert
This study shows that MDT-15 and HIZR-1 cooperate to regulate metal detoxification and zinc storage in C. elegans, with partial conservation in mammals.
PLoS Genetics · Dec 9, 2019Peer-reviewedGenetics