Author

Peter J. McGuire

National Institutes of HealthORCID 0000-0001-5601-3044Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Andrew Phillip WestiD· 1 shared Brian Robert HoffmanniD· 1 shared Camila Guerra MartineziD· 1 shared Carolyn L. CannoniD· 1 shared Himani Datta Majumdar· 1 shared Jessica K. WongiD· 1 shared Jordyn J. VanPortflietiD· 1 shared Kanneboyina NagarajuiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Andrew Phillip WestORCID

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2 papers

Recent·Most cited

ImmunologyNature CommunicationsPeer-reviewedMay 20, 2025

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease

Jordyn J. VanPortfliet, Yuanjiu Lei, Muthumeena Ramanathan…·Andrew Phillip West

This study identifies caspase-11 as a driver of macrophage hyperinflammation in Polg-related mitochondrial disease models, linking IFN-I signaling to exacerbated infection outcomes.

18 citationstop 4%

mouseexperimental assay

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Molecular BiologyJournal of Inherited Metabolic DiseasePeer-reviewedJun 9, 2019

AMPK Signaling Regulates Expression of Urea Cycle Enzymes in Response to Changes in Dietary Protein Intake

Sandra Kirsch Heibel, Peter J. McGuire, Nantaporn Haskins…·Ljubica Caldovic

The paper identifies AMPK signaling as a regulator of urea cycle enzyme expression in response to dietary protein intake changes in mice and human hepatocytes.

12 citations

mousehuman

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