ImmunologyNature CommunicationsPeer-reviewed
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease
Jordyn J. VanPortfliet, Yuanjiu Lei, Muthumeena Ramanathan…·Andrew Phillip West
This study identifies caspase-11 as a driver of macrophage hyperinflammation in Polg-related mitochondrial disease models, linking IFN-I signaling to exacerbated infection outcomes.
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