Kiara L. Rodríguez-Acevedo

The paper shows that reducing Cdk5 gene expression via epigenetic editing impairs memory in both male and female mice, highlighting sex-independent epigenetic regulation of hippocampal memory.

The paper investigates Xist RNA's role in X chromosome inactivation dynamics in B cells, finding Xist-dependent and independent epigenetic mechanisms that maintain XCI memory.

The paper investigates sex differences in memory vulnerability to acute traumatic stress, finding that estrogen and its receptors play a role in both males and females.

The paper investigates sex-specific regulation of hippocampal Cdk5 in mice under different stress paradigms, finding male-specific changes in mRNA and protein levels under combined stress conditions.

The paper uses CRISPR-based epigenetic editing to manipulate Cartpt expression in mice, showing it affects cocaine memory acquisition and extinction.

This paper demonstrates that CRISPR-mediated transcriptional activation can upregulate SYNGAP1 in a mouse model of SRID and human neurons, rescuing deficits without targeting mutations.